Affiliation:
1. Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok Branch of the Far Eastern Scientific Center for Physiology and Pathology of Respiration, Vladivostok, Russia
Abstract
Atmospheric pollution causes enormous damage to public health worldwide resulting in millions of deaths annually, and reducing both life expectancy and quality of life. Suspended particulate matter (SPM) in the air triggers immune system responses, which in turn determines a wide range of diseases based on chronic inflammation. However, many issues regarding the relationship between air pollution and the development and course of pathologies remain unresolved. The present review summarizes the data of domestic and foreign publications regarding the effect of atmospheric SPM on the immune system. The article reveals the effect of SPM on immunocompetent cells and investigates cellular and molecular response mechanisms of the body. The data presented in the review imply the need for further studies of immune system response mechanisms under the impact of atmospheric SPM.
Publisher
LLC Science and Innovations
Reference87 articles.
1. WHO global air quality guidelines. Particulate matter (PM2.5 and PM10), ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide. Geneva: World Health Organization. 2021; 290 p. https://www.who.int/publications/i/item/9789240034228.
2. Kim KH, Kabir E, Kabir S. A review on the human health impact of airborne particulate matter. Environ Int 2015; 74: 136-143. https://doi.org/10.1016/j.envint.2014.10.005.
3. Thompson JE. Airborne particulate matter: Human exposure and health effects. J Occup Environ Med 2018; 60(5): 392-423. https://doi.org/10.1097/JOM.0000000000001277.
4. Puett RC, Yanosky JD, Mittleman MA, Montresor-Lopez J, Bell RA, Crume TL, et al. Inflammation and acute traffic-related air pollution exposures among a cohort of youth with type 1 diabetes. Environ Int 2019; 132: 105064. https://doi.org/10.1016/j.envint.2019.105064.
5. Marrot L. Pollution and sun exposure: A deleterious synergy. Mechanisms and opportunities for skin protection. Curr Med Chem 2018; 25(40): 5469-5486. https://doi.org/10.2174/0929867324666170918123907.