Affiliation:
1. Chuvash State University
Abstract
Secondary amyloidosis is a frequent complication of chronic inflammatory processes. That is why comorbid conditions are possible in which the underlying disease is combined with systemic amyloidosis. Once started, secondary amyloidosis becomes an independent process that complicates the course of the underlying disease that caused it and often becomes the main cause of death of the patient. The aim is to present a case report of psoriasis combined with systemic amyloidosis. Material and methods. The material was a clinical case of psoriasis combined with AL-amyloidosis in a 36-year-old patient who was in a state of persistent clinical remission for 12 years after treatment with melphalan in combination with the introduction of autologous stem cells. From the biopsy material of a psoriatic plaque, we made paraffin sections with a thickness of 5 microns, which were stained with hematoxylin and eosin, or hematoxylin and Congo Red, or thioflavin and subjected to light, polarization and luminescence microscopy. Results. Amyloid deposits were found in the dermis of the patient's psoriatic plaque, which were detected by examining sections stained with Congo Red in polarized light and thioflavin under luminescent microscopy. Conclusions. Despite a persistent clinical remission of systemic AL-amyloidosis, comorbid to preceding psoriasis, obtained as a result of the use of a modern pathogenetic method for treating such conditions – a course of melphalan in combination with autologous stem cell support – amyloid deposits in the psoriatic duty plaque were found in the examined patient.
Publisher
I.N. Ulianov Chuvash State University
Subject
Management Science and Operations Research,Mechanical Engineering,Energy Engineering and Power Technology
Reference21 articles.
1. Badokin V.V. Vtorichnyi sistemnyi amiloidoz u bol’nykh psoriaticheskim artritom [Secondary systemic amyloidosis in patients with psoriatic arthritis]. Nauchno-prakticheskaya revmatologiya, 2001, no. 4, pp. 84–90.
2. Pirogova O.V., Kudyasheva O.V., Smirnova A.G., Porunova V.V. et al. Rol’ transplantatsii autologichnykh gemopoeticheskikh stvolovykh kletok v lechenii patsientov s sistemnym AL amiloidozom [The role of autologous hematopoietic stem cell transplantation in the treatment of patients with systemic AL amyloidosis]. Klinicheskaya onkogematologiya, 2023, vol. 16, no. 2, pp. 128–136.
3. Baldwin A.J., Knowles T.P., Tartaglia G.G. et al. Metastability of native proteins and the phenomenon of amyloid formation. J Am Chem Soc, 2011, vol. 133(36), pp. 14160–14163. DOI: 10.1021/ja2017703.
4. Benson M.D., Buxbaum J.N., Eisenberg D.S. et al. Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid, 2018, vol. 25, no. 4, pp. 215–219. DOI: 10.1080/13506129.2018.1549825.
5. Bu J., Ding R., Zhou L., Chen X., Shen E. Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review. Front Immunol., 2022, no. 13, 880201. DOI: 10.3389/fimmu.2022.880201.