Hyperthermic Intraperitoneal Chemotherapy May Damage Renal Function and Cause Serum Electrolyte Disturbance: A Retrospective Observational Study

Abstract

Objective: The objective of this study was to evaluate the efficacy of postoperative hyperthermic intraperitoneal chemotherapy (HIPEC) on bone marrow hematopoiesis, liver and kidney function, and serum electrolytes for patients who underwent open radical gastrectomy, and investigate the variation tendency of above indicators. Materials and Methods: The clinical data of 153 patients who underwent open radical gastrectomy were retrospectively analyzed and were divided into HIPEC group (n=83) and control group (n=70). Repeated analysis of variance was used to analyze the variation tendency of bone marrow hematopoiesis, liver and kidney function, and serum electrolytes in the HIPEC and control group, respectively, and then made a comparison between the 2 groups. Results: There were statistical differences in alanine aminotransferase (P=0.034), phosphorus (P +) (P<0.05), potassium (K+) (P=0.023), sodium (Na+) (P<0.001), and chloride (Cl−) (P=0.008) between HIPEC and control group. All outcome indicators changed significantly over time (P<0.05). No significant difference was found in hemoglobin, white blood cell, platelet, aspartate aminotransferase, total bilirubin, or uric acid between the 2 treatment groups at each time point. On the next day after HIPEC treatment, the levels of blood urea nitrogen, creatinine, and P + were higher in the HIPEC group, whereas the calcium (Ca+), magnesium (Mg+), and K+ levels of HIPEC group tended to be lower. However, the effects of HIPEC on alanine aminotransferase, Na+, and Cl− levels needed to be further explored. Conclusions: HIPEC treatment after open radical gastrectomy has no significant effect on hematopoietic bone marrow and liver function but may damage renal function; reduce Ca+, Mg+, K+ levels; and increase P + level.