Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes

Author:

Ladwig Nicholas R.,Umetsu Sarah E.,Zaloudek Charles,Rabban Joseph,Garg Karuna

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Obstetrics and Gynecology,Pathology and Forensic Medicine

Reference33 articles.

1. Endometrioid carcinomas of the uterine corpus with sex cord-like formations, hyalinization, and other unusual morphologic features: a report of 31 cases of a neoplasm that may be confused with carcinosarcoma and other uterine neoplasms;Murray;Am J Surg Pathol,2005

2. Aberrant nuclear beta-catenin expression in the spindle or corded cells in so-called corded and hyalinized endometrioid carcinomas. Another critical role of the unique morphological feature;Wani;Histol Histopathol,2009

3. Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma;Liu;J Natl Cancer Inst,2014

4. CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence;Kurnit;Mod Pathol,2017

5. Clinicopathologic and immunohistochemical correlates of CTNNB1 mutated endometrial endometrioid carcinoma;Costigan;Int J Gynecol Pathol,2019

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