Bibliometric Analysis of the Role of Pyroptosis in Sepsis

Abstract

ABSTRACT Background: Emerging evidence has demonstrated that pyroptosis plays a vital role in the development of sepsis. However, few studies have examined this field systemically. We performed the first bibliometric analysis to draw conclusions from and visualize related publications to determine the trends and hotspots in pyroptosis research on sepsis. Methods: A total of 267 publications were retrieved from the Web of Science Core Collection from January 1, 2007 to December 21, 2021. Then, VOSviewer and CiteSpace were used for further analysis. Results: The publications in this field showed an upward trend annually, especially after 2014. Most of the articles were authored by Chinese and American scholars and published in Frontiers in Immunology. Timothy R Billiar published the most related articles, while Shi JJ was cited the most frequently. Co-citation analysis showed that the top 5 co-cited references in this field were in Nature and JAMA's leading co-cited journals. The keywords in this field revolve around the mechanisms of pyroptosis. Guanylate binding protein might be the hotspot, however, based on cluster analysis. Conclusion: The growing interest of researchers in pyroptosis in sepsis reflects the increasing understanding of its underlying mechanisms and the discovery of more clinical effects. These findings suggest that pyroptosis may hold significant potential as a therapeutic target for various diseases.