Effect of Vasopressors and Vasodilators on Kidney Medulla Oxygenation

Author:

Honore Patrick M1ORCID,Blackman Sydney2,Perriens Emily3,Oueslati Ilann3,Al-Sammour Christophe3,Bankier David Vidal3,Bendoumou Maha3,Ramos-Prieto Maya3,Bulpa Pierre1,Robert Arnaud1,Nendumba Gauthier1,Vornicu Ovidiu14,Evrard Patrick1,Dincq Anne-Sophie14,Michaux Isabelle1

Affiliation:

1. ICU Department, Centre Hospitalier Universitaire, UCL Godinne Namur, UCLouvain Medical School, Godinne 5530, Belgium.

2. Centre Hospitalier Interrégional Edith Cavell, Brussels 1000, Belgium.

3. Faculty of Medicine, Université Libre de Bruxelles, Brussels 1000, Belgium.

4. Anethesiology Department, Centre Hospitalier Universitaire, UCL Godinne Namur, UCLouvain Medical School, Godinne 5530, Belgium.

Abstract

ABSTRACT This narrative review provides a comprehensive summary of research findings up to 2023 regarding the impact of vasopressors and vasodilators on medullary oxygenation during cardiopulmonary bypass and septic shock. It encompasses a thorough evaluation of all current vasopressors and vasodilators. Among vasodilators, levosimendan demonstrates superior efficacy, particularly in cases of heart failure following cardiac surgery. In the context of hypotension during such procedures, vasopressin emerges as the most effective vasopressor. In cases of hypotensive septic shock, both vasopressin and angiotensin II appear to be superior in preserving medullary oxygenation. However, it is imperative to emphasize the need for more robust data and randomized controlled human trials to validate these initial findings. Currently, it would be premature to offer definitive clinical recommendations on this matter.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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