Diagnosis of Fibrillary Glomerulonephritis with Positive Immunoglobulin A-κ Deposits Presenting as Membranous Nephropathy Using Immunoelectron Microscopy: A Case Report and Literature Review

Abstract

ABSTRACT Fibrillary glomerulonephritis (FGN) is a rare disease characterized by randomly arranged fibrils with a diameter of 10–30 nm on immunoelectron microscopy. Clinically, renal insufficiency, hypertension, hematuria, and proteinuria are the typical symptoms of FGN. Currently, there are limited treatment options for FGN, and transplant recurrence is common. We reported the case of a middle-aged Chinese woman diagnosed with FGN with positive immunoglobulin A-κ deposits presenting as membranous nephropathy.