The “Atypical Glandular Cells” Papanicolaou Test: Recent Updates

Author:

Li Zaibo1,Zhao Chengquan1

Affiliation:

1. From the *The Ohio State University Wexner Medical Center, Columbus, OH; and †Magee Women's Hospital and University of Pittsburgh, Pittsburgh, PA.

Abstract

AbstractAtypical glandular cells are gynecologic cytology abnormalities representing glandular cells with morphologic changes that exceed obvious reactive/reparative changes, but fall short of an interpretation of adenocarcinoma either quantitatively or qualitatively. This cytological diagnosis occurs in less than 1% of the results of gynecologic cytology tests (0.2%–0.8%) but potentially reflects a wide range of conditions, from benign changes and cervical squamous/glandular precursor lesions, to invasive cervical or other gynecologic cancers. In this article, we aim at reviewing different subcategories, potential ancillary studies, histological follow-up results, and clinical management of atypical glandular cells.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Pathology and Forensic Medicine

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