Exacerbation of Kaposi sarcoma following BRAF/MEK inhibitor therapy in a melanoma patient: a case report and mechanistic insight-Reference-Cited by-同舟云学术

Exacerbation of Kaposi sarcoma following BRAF/MEK inhibitor therapy in a melanoma patient: a case report and mechanistic insight

Published:2024-07-22 Issue: Volume: Page:
ISSN:0960-8931
Container-title:Melanoma Research
language:en
Short-container-title:

Author:

Tsimpidakis Antonios¹,Koumprentziotis Ioannis-Alexios¹,Mastoraki Evanthia¹,Plaka Michaella¹,Gogas Helen²,Stratigos Alexander¹,Nikolaou Vasiliki¹

Affiliation:

1. First Department of Dermatology-Venereology, Medical School, National and Kapodistrian University of Athens, ‘A. Sygros’ Hospital for Skin and Venereal Diseases

2. First Department of Medicine, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

Abstract

We present a case of a 75-year-old male patient who experienced a severe exacerbation of his Kaposi sarcoma lesions, which have remained clinically stable for a year, following treatment with BRAF/mitogen-activated protein kinase inhibitors for his coexisting melanoma. In this case, we present the possibility that BRAF/MEK inhibition may be mechanistically associated with the progression of Kaposi sarcoma and briefly discuss the potential mechanisms behind this phenomenon.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Reference10 articles.

1. Kaposi sarcoma.;Cesarman;Nat Rev Dis Primers,2019

2. The T-cell immune response against Kaposi’s sarcoma-associated herpesvirus.;Robey;Adv Virol,2010

3. Drug resistance of BRAF-mutant melanoma: review of up-to-date mechanisms of action and promising targeted agents.;Rossi;Eur J Pharmacol,2019

4. Incidence and relative risk of cutaneous squamous cell carcinoma with single-agent BRAF inhibitor and dual BRAF/MEK inhibitors in cancer patients: a meta-analysis.;Peng;Oncotarget,2017

5. B-Raf-dependent expression of vascular endothelial growth factor-A in Kaposi sarcoma-associated herpesvirus-infected human B cells.;Akula;Blood,2005