PRENATAL MATERNAL CHARACTERISTICS ASSOCIATED WITH RETINOPATHY OF PREMATURITY

Author:

Strawbridge Jason C.1,Chu Alison2,Dammann Olaf345,Hanson Justin1,Janzen Carla6,Tsui Irena7

Affiliation:

1. David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California;

2. Division of Neonatology and Developmental Biology, Department of Pediatrics, University of California at Los Angeles, Los Angeles, California;

3. Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts;

4. Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany;

5. Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway;

6. Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, California; and

7. Division of Retina and Vitreous Diseases, Stein and Doheny Eye Institutes, University of California at Los Angeles, Los Angeles, California.

Abstract

Purpose: Determine whether prenatal maternal characteristics such as sociodemographic characteristics, comorbidities, or pregnancy complications affect retinopathy of prematurity (ROP) development. Methods: Medical records of 236 mother–infant dyads from our institution were reviewed, only including dyads in which infants were born at 30 weeks gestational age or earlier. The primary outcome measure was the risk of ROP (defined Stage 1 or greater in either eye) and its association with prenatal maternal variables. Results: Maternal Medicaid insurance, smoking during pregnancy, and chorioamnionitis were associated with an increased risk of ROP. For Medicaid insurance and chorioamnionitis, these risks were not appreciably altered by adjustment for potential confounders. Conclusion: These results suggest that several prenatal maternal factors may independently affect the risk of ROP in preterm infants. Validation of our findings could aid in the identification of infants at high risk for ROP based on prenatal clinical features.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Ophthalmology,General Medicine

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