Factors associated with outcomes of suprachoroidal hemorrhage: an individual participant data systematic review

Abstract

Purpose: To determine factors associated with visual and anatomic outcomes of suprachoroidal hemorrhage (SCH) in studies published between 1990 and 2022. Methods: Individual participant data (IPD) systematic review. The protocol was prospectively registered on Open Science Framework (https://osf.io/69v3q/). PubMed, EMBASE, Web of Science, and Google Scholar were searched for peer-reviewed studies of SCH with ≥3 patients published between January 1, 1990, and September 1, 2022. The primary outcome was the change in logarithm of the minimum angle of resolution (logMAR) visual acuity (VA) from the time of SCH diagnosis to last follow-up. Results: 413 eyes from 49 studies were included, with mean (SD) age 60.8 (22.4) years and mean (SD) follow-up of 13.8 (12.6) months. Among 145 eyes with at least 6 months of follow-up, the mean (SD) gain in VA was -0.98 (0.89) logMAR. In multivariable regression, treatment with systemic steroids was associated with greater improvement in logMAR VA (adjusted mean (SE) -1.29 (0.09) versus -0.16 (0.30) for no systemic steroids; P < 0.001) and greater odds of achieving anatomic success (adjusted OR 10.59, 95% CI 2.59 to 43.3; P = 0.001). Conclusions: The use of systemic steroids was associated with better visual and anatomic outcomes for SCH.