Affiliation:
1. Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; and
2. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Abstract
Purpose:
To report the anatomic outcomes and retinal structure changes from lens-sparing vitrectomy (LSV) for eyes with Stage 3 or 4 familial exudative vitreoretinopathy (FEVR).
Methods:
Overall, 133 consecutive eyes of 119 patients with Stage 3 (51 eyes) or 4 (82 eyes) FEVR who underwent LSV between January 2012 and May 2023 were retrospectively reviewed.
Results:
One hundred twenty-nine eyes (97.0%) achieved traction relief through one LSV operation. The extent of retinal detachment improved in 98 eyes (73.7%), remained stable in 32 eyes (24.1%), and progressed in three eyes (2.3%). At long-term follow-up, 39 (29.3%) and 60 (45.1%) eyes had completely or partially reattached retina, respectively. The median change of venular angle was 3.6° (95% CI, 3.5–10.5; P < 0.001) and −9.9° (95% CI, −15.8 to −4.6; P < 0.001) for temporal and nasal vessels, respectively. The mean disk–fovea distance was 0.3 papillary diameter shorter (95% CI, −0.4 to −0.2; P < 0.001), and the mean temporal venular arcade distance was 0.02 papillary diameter larger (95% CI, −0.16 to 0.21; P = 0.361).
Conclusion:
These results suggest that LSV can relieve vitreoretinal traction and reattach the retina in late-stage FEVR eyes. Improvements in temporal and nasal venular angle and disk–fovea distance reflect positive retinal structure changes for patients.
Funder
the Shanghai Science and Technology Committee
National Natural Science Foundation of China
Publisher
Ovid Technologies (Wolters Kluwer Health)