PHOTOBIOMODULATION THERAPY FOR LARGE SOFT DRUSEN AND DRUSENOID PIGMENT EPITHELIAL DETACHMENT IN AGE-RELATED MACULAR DEGENERATION

Author:

Benlahbib Manal1,Cohen Salomon Yves12,Torrell Nuria1,Colantuono Donato1,Crincoli Emanuele1,Amoroso Francesca1,Semoun Oudy1,Jung Camille3,Souied Eric H.1

Affiliation:

1. Department of Ophthalmology, Department of Ophthalmology, Centre Hospitaliser Intercommunal de Creteil, University of Paris Est-Creteil, Creteil, France;

2. Ophthalmology Center for Imaging and Laser, Paris, France; and

3. Clinical Research Center, Centre Hospitaliser Intercommunal de Creteil, Creteil, France.

Abstract

Purpose: To evaluate visual acuity and morphologic changes after photobiomodulation (PBM) for patients affected with large soft drusen and/or drusenoid pigment epithelial detachment associated with dry age-related macular degeneration. Method: Twenty eyes with large soft drusen and/or drusenoid pigment epithelial detachment age-related macular degeneration were included and treated using the LumiThera Valeda Light Delivery System. All patients underwent two treatments per week for 5 weeks. Outcome measures included best-corrected visual acuity, microperimetry-scotopic testing, drusen volume, central drusen thickness, and quality of life score at baseline and month 6 (M6) follow-up. Data of best-corrected visual acuity, drusen volume, and central drusen thickness were also recorded at week 5 (W5). Results: Best-corrected visual acuity significantly improved at M6 with a mean score gain of 5.5 letters (P = 0.007). Retinal sensitivity decreased by 0.1 dB (P = 0.17). The mean fixation stability increased by 0.45% (P = 0.72). Drusen volume decreased by 0.11 mm3 (P = 0.03). Central drusen thickness was reduced by a mean of 17.05 µm (P = 0.01). Geographic atrophy area increased by 0.06 mm2 (P = 0.01) over a 6-month follow-up, and quality of life score increased by 3,07 points on average (P = 0.05). One patient presented a drusenoid pigment epithelial detachment rupture at M6 after PBM treatment. Conclusion: The visual and anatomical improvements in our patients support previous reports on PBM. PBM may provide a valid therapeutic option for large soft drusen and drusenoid pigment epithelial detachment age-related macular degeneration and may potentially slow the natural course of the disease.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Ophthalmology,General Medicine

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