Facial Nerve Tractography Using Diffusion MRI: A Comparison of Acquisition b-Values and Single- and Multifiber Tracking Strategies

Author:

Epprecht LorenzORCID,Zekelman Leo,Reinshagen Katherine L.1,Xie Guoqiang2,Norton Isaiah3,Kikinis Ron3,Makris Nikos,Piccirelli Marco4,Huber Alexander,Lee Daniel J.5,Zhang Fan3,O'Donnell Lauren J.3

Affiliation:

1. Department of Radiology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston MA, USA

2. Department of Neurosurgery, Nuclear Industry 215 Hospital of Shaanxi Province, Xianyang, China

3. Radiology

4. Department of Neuroradiology, Clinical Neurocenter, University of Zurich, University Hospital of Zurich, Zurich, Switzerland

5. Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA

Abstract

Abstract: Hypothesis This study investigates the impact of different diffusion magnetic imaging (dMRI) acquisition settings and mathematical fiber models on tractography performance for depicting cranial nerve (CN) VII in healthy young adults. Background The aim of this study is to optimize visualization of CN VII for preoperative assessment in surgeries near the nerve in the cerebellopontine angle, reducing surgery-associated complications. The study analyzes 100 CN VII in dMRI images from the Human Connectome Project, using three separate sets with different b values (b = 1,000 s/mm2, b =2,000 s/mm2, b =3,000 s/mm2) and four different tractography methods, resulting in 1,200 tractographies analyzed. Results The results show that multifiber and free water (FW) compartment models produce significantly more streamlines than single-fiber tractography. The addition of an FW compartment significantly increases the mean streamline fractional anisotropy (FA). Expert quality ratings showed that the highest rated tractography was the 1 tensor (1T) method without FW at b values of 1,000 s/mm2. Conclusions In this young and healthy cohort, best tractography results are obtained by using a 1T model without a FW compartment in b =1,000 diffusion MR images. The FW compartment increased the contrast between streamlines and cerebrospinal fluid (higher mean streamline FA). This finding may help ongoing research to improve CN VII tractography results in tumor cases where the nerve is often stretched and thinned by the tumor.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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