The Promise of Endovascular Neurotechnology: A Brain-Computer Interface to Restore Autonomy to People with Motor Impairment

Abstract

Abstract This Joel A. DeLisa Lecture on endovascular brain-computer interfaces was presented by Dr. Thomas Oxley on February 23, 2023, at the Association of Academic Physiatrists Annual Scientific Meeting. The lecture described how brain-computer interfaces (BCIs) replace lost physiological function to enable direct communication between the brain and external digital devices such as computers, smartphones, and robotic limbs. Specifically, the potential of a novel endovascular BCI technology was discussed. The BCI uses a stent-electrode array delivered via the jugular vein and is permanently implanted in a vein adjacent to the motor cortex. In a first-in-human clinical trial, participants with upper limb paralysis who received the endovascular BCI could use the system independently and at home to operate laptop computers for various instrumental activities of daily living. An FDA-approved trial of the endovascular BCI in the United States is in progress. Future development of the system will provide recipients with continuous autonomy through digital access with minimal caregiver assistance. Physiatrists and occupational therapists will have a vital role in helping people with paralysis achieve the potential of implantable BCIs.