Four-factor Prothrombin Complex Concentrate for the Management of Patients Receiving Direct Oral Activated Factor X Inhibitors

Author:

Grottke Oliver1,Schulman Sam1

Affiliation:

1. From the Department of Anesthesiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Germany (O.G.); Thrombosis and Atherosclerosis Research Institute and Department of Medicine, McMaster University, Hamilton, Canada (S.S.); and Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, Russia (S.S.).

Abstract

Factor Xa inhibitors prevent thrombosis but are associated with severe or life-threatening bleeding. Here, the authors present data on four-factor prothrombin complex concentrates in management of anticoagulation-associated bleeding and restoring hemostasis, including recent results from the UPRATE study.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Anesthesiology and Pain Medicine

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