1. From the Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada (N.M.G., B.E.S.); Sick Kids Research Institute, Program in Cell Biology (N.M.G.) and Program in Neuroscience and Mental Health (B.E.S.), Toronto, Ontario, Canada; Department of Pediatrics and Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine,