1. From the Department of Medical Sciences, Clinical Physiology (G.H.), and the Department of Surgical Sciences, the Hedenstierna Laboratory (G.P., A.L.), Uppsala University, Sweden; the Department of Anaesthesia and Intensive Care, Bispebjerg and Frederiksberg Hospital, University of Copenhagen (C.S.M.); the Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhage