1. From the Department of Anesthesiology, Intensive Care Medicine and Pain Medicine (H.B., I.B., T.V., A.R.), and the Institute for Medical Biometry, Epidemiology and Medical Informatics (S.W.), Saarland University, University Medical Center, Homburg/Saar, Germany; the Department of Anesthesiology, Intensive Care and Pain Medicine, Orthopedic University Hospital, Frankfurt, Germany (P.K.); the Depar