Hypereosinophilic Syndrome with Pulmonary Involvement in Ulcerative Colitis-Reference-Cited by-同舟云学术

Hypereosinophilic Syndrome with Pulmonary Involvement in Ulcerative Colitis

Published:2023-06-09 Issue:3 Volume:4 Page:e320
ISSN:2691-171X
Container-title:JPGN Reports
language:en
Short-container-title:

Author:

Bashir Anam¹,Cabrera Jose M.²,Suchi Mariko³,Pelz Barry J.⁴

Affiliation:

1. Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI

2. Associate Professor, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI

3. Associate Professor, Department of Pathology and Laboratory Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, WI

4. Assistant Professor, Division of Allergy and Immunology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI

Abstract

Reactive eosinophilia is associated with inflammatory bowel disease and is more common in patients with ulcerative colitis (UC) compared with Crohn’s disease. The prevalence rate of peripheral blood eosinophilia in patients with inflammatory bowel disease has been described to be as high as 30%–40% of patients in a pediatric study. The coexistence of hypereosinophilic syndrome (HES) and UC is uncommon. We present a 15-year-old boy with UC associated with HES who presented with chest pain and shortness of breath. Laboratory evaluation showed marked eosinophilia. Alternative causes of eosinophilia including eosinophilic leukemia, infections, or drug-induced eosinophilic pneumonia were ruled out. The patient was ultimately diagnosed with HES responsive to mepolizumab.

Publisher

Wiley

Subject

General Earth and Planetary Sciences,General Environmental Science

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