The Discover In-Hospital Cardiac Arrest (Discover IHCA) Study: An Investigation of Hospital Practices After In-Hospital Cardiac Arrest-Reference-Cited by-同舟云学术

The Discover In-Hospital Cardiac Arrest (Discover IHCA) Study: An Investigation of Hospital Practices After In-Hospital Cardiac Arrest

Published:2024-09 Issue:9 Volume:6 Page:e1149
ISSN:2639-8028
Container-title:Critical Care Explorations
language:en
Short-container-title:

Author:

Andrea Luke¹^ORCID,Herman Nathaniel S.¹,Vine Jacob²,Berg Katherine M.²³,Choudhury Saiara⁴,Vaena Mariana⁵,Nogle Jordan E.⁶,Halablab Saleem M.⁷,Kaviyarasu Aarthi⁷,Elmer Jonathan⁸⁹¹⁰,Wardi Gabriel¹¹¹²,Pearce Alex K.¹²,Crowley Conor¹³,Long Micah T.¹⁴,Herbert J. Taylor¹⁵,Shipley Kipp¹⁶,Bissell Turpin Brittany D.¹⁷¹⁸,Lanspa Michael J.¹⁹,Green Adam²⁰²¹,Ghamande Shekhar A.²²,Khan Akram²³,Dugar Siddharth²⁴,Joffe Aaron M.²⁵,Baram Michael²⁶,March Cooper²⁷,Johnson Nicholas J.²⁷²⁸,Reyes Alexander²⁹,Denchev Krassimir³⁰,Loewe Michael³¹³²,Moskowitz Ari¹,

Affiliation:

1. Bronx Center for Critical Care Outcomes and Resuscitation Research, Division of Critical Care Medicine, Montefiore Medical Center, Bronx, NY.

2. Center for Resuscitation Science, Beth Israel Deaconess Medical Center, Boston, MA.

3. Division of Pulmonary and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA.

4. Division of Pulmonary, Allergy, and Critical Care Medicine, Hennepin County Medical Center, Minneapolis, MN.

5. Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.

6. Department of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, NC.

7. Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA.

8. Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.

9. Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.

10. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

11. Department of Emergency Medicine, University of California San Diego, La Jolla, CA.

12. Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California San Diego, La Jolla, CA.

13. Division of Pulmonary and Critical Care Medicine, Lahey Hospital and Medical Center, Burlington, MA.

14. Department of Anesthesiology, Division of Critical Care, University of Wisconsin School of Medicine & Public Health, Madison, WI.

15. Division of Critical Care Medicine, Department of Anesthesiology, Duke University School of Medicine, Durham, NC.

16. Critical Care Outreach Team, Vanderbilt University Medical Center, Nashville, TN.

17. Department of Pharmacy, University of Kentucky, Lexington, KY.

18. Department of Pharmacy, Ephraim McDowell Regional Medical Center, Danville, KY.

19. Pulmonary Division, Department of Medicine, Intermountain Medical Center, Murray, UT.

20. Division of Critical Care, Cooper University Health Care, Camden, NJ.

21. Cooper Medical School of Rowan University, Camden, NJ.

22. Division of Pulmonary, Critical Care and Sleep Medicine, Baylor Scott and White Medical Center, Baylor College of Medicine, Temple, TX.

23. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Oregon Health and Science University School of Medicine, Portland, OR.

24. Department of Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, OH.

25. Department of Anesthesiology, Valleywise Health Medical Center, Creighton University School of Medicine, Phoenix, AZ.

26. Korman Lung Center, Thomas Jefferson University, Philadelphia, PA.

27. Department of Emergency Medicine, University of Washington, Seattle, WA.

28. Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, WA.

29. Ascension Saint Agnes Hospital, Baltimore, MD.

30. Department of Anesthesiology, Wayne State University, Pontiac, MI.

31. Our Lady of the Lake Regional Medical Center, Baton Rouge, LA.

32. Louisiana State University Health Sciences Center, Emergency Medicine Residency Program, Baton Rouge Campus, Baton Rouge, LA.

Abstract

IMPORTANCE: In-hospital cardiac arrest (IHCA) is a significant public health burden. Rates of return of spontaneous circulation (ROSC) have been improving, but the best way to care for patients after the initial resuscitation remains poorly understood, and improvements in survival to discharge are stagnant. Existing North American cardiac arrest databases lack comprehensive data on the post-resuscitation period, and we do not know current post-IHCA practice patterns. To address this gap, we developed the Discover In-Hospital Cardiac Arrest (Discover IHCA) study, which will thoroughly evaluate current post-IHCA care practices across a diverse cohort. OBJECTIVES: Our study collects granular data on post-IHCA treatment practices, focusing on temperature control and prognostication, with the objective of describing variation in current post-IHCA practice. DESIGN, SETTING, AND PARTICIPANTS: This is a multicenter, prospectively collected, observational cohort study of patients who have suffered IHCA and have been successfully resuscitated (achieved ROSC). There are 24 enrolling hospital systems (23 in the United States) with 69 individual enrolling hospitals (39 in the United States). We developed a standardized data dictionary, and data collection began in October 2023, with a projected 1000 total enrollments. Discover IHCA is endorsed by the Society of Critical Care Medicine. INTERVENTIONS, OUTCOMES, AND ANALYSIS: The study collects data on patient characteristics including pre-arrest frailty, arrest characteristics, and detailed information on post-arrest practices and outcomes. Data collection on post-IHCA practice was structured around current American Heart Association and European Resuscitation Council guidelines. Among other data elements, the study captures post-arrest temperature control interventions and post-arrest prognostication methods. Analysis will evaluate variations in practice and their association with mortality and neurologic function. CONCLUSIONS: We expect this study, Discover IHCA, to identify variability in practice and outcomes following IHCA, and be a vital resource for future investigations into best-practice for managing patients after IHCA.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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