The efficacy of Hemospray in managing bleeding related to gastrointestinal tumors: systematic review and meta-analysis

Author:

Abosheaishaa Hazem1,Abdallfatah Abdallfatah2,Ahmed Omar T.3,Elfert Khaled4,Mohamed Islam5,AlabdulRazzak Iyiad6,Abdalla Monzer7,Sethi Arashi8,Abdelhalim Omar9,Gayam Vijay Reddy10,Eskaros Saphwat11,Boulay Brian12

Affiliation:

1. Department of Internal Medicine, Icahn School of Medicine at Mount Sinai/NYC Health + Hospitals Queens, New York City, New York, USA

2. Faculty of Medicine, October 6 University, Giza, Egypt

3. Department of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois

4. Department of Internal Medicine, St. Barnabas Hospital Health System, New York City, New York

5. Department of Internal Medicine, University of Missouri-Kansas City, Kansas City, Kansas

6. Department of Internal Medicine, St. Elizabeth’s Medical Center, Boston, Massachusetts

7. Department of Internal Medicine, Ascension Saint Francis Hospital, Evanston, Illinois

8. Department of Internal Medicine, Icahn school of medicine at Mount Sinai NYC H&H/Queens

9. Department of Internal Medicine, Icahn School of Medicine at Mount Sinai | Queens Hospital Center, New York City, New York

10. Department of Internal Medicine, University of southwestern Medical Center, Dallas, Texas

11. Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York

12. Department of Gastroenterology and Hepatology, University of Illinois Hospital & Health Sciences System, Illinois, Chicago, USA

Abstract

Introduction Gastrointestinal (GI) bleeding stemming from malignant tumors is increasingly recognized, due to advancements in oncology and detection methods. Traditional endoscopic hemostatic techniques have shown variable success rates in managing hemorrhagic GI neoplasms. Hemospray, an emerging endoscopic hemostatic powder, offers promise in treating upper GI bleeding, potentially extending its utility to neoplastic bleeding sites. This meta-analysis aims to evaluate Hemospray’s efficacy in managing bleeding related to GI tumors. Methods We searched Embase, Scopus, Web of Science, Medline/PubMed, and Cochrane. Inclusion criteria encompassed studies focusing on malignancy-related GI bleeding and interventions utilizing Hemospray. Comparative studies contrasted Hemospray with standard endoscopic treatments (SET), while noncomparative studies assessed Hemospray’s efficacy independently. The risk of bias was assessed using appropriate tools, and statistical analyses were performed using Review Manager and open Meta analyst software. Results We included 19 studies in our meta-analysis. Hemospray demonstrated higher rates of immediate hemostasis compared to SET (odds ratio: 17.14, 95% confidence interval: 4.27–68.86), with consistent outcomes across studies. Rebleeding rates at 14 and 30 days were comparable between Hemospray and SET groups, suggesting similar efficacy in long-term hemostasis. Hemospray showed a significantly lower need for nonendoscopic hemostasis compared to SET (odds ratio: 0.51, 95% confidence interval: 0.30–0.87), indicating a potential reduction in supplementary interventions. Safety assessments revealed no confirmed adverse events directly linked to Hemospray. Conclusion This meta-analysis highlights Hemospray’s efficacy in achieving immediate hemostasis in GI tumor-related bleeding, with potential benefits in reducing supplementary interventions and improving patient outcomes. Despite comparable rebleeding rates, Hemospray emerges as a valuable adjunctive therapy in managing malignant GI bleeding.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Reference43 articles.

1. Management of bleeding in patients with advanced cancer.;Pereira;Oncologist,2004

2. Hematologic abnormalities in patients with nonhematologic malignancies.;Dutcher;Hematol Oncol Clin North Am,1987

3. Use of the endoscopically applied Hemostatic Powder TC-325 in cancer-related upper GI hemorrhage: preliminary experience (with video).;Chen;Gastrointest Endosc,2012

4. Clinical application of argon plasma coagulation in endoscopic hemostasis for non-ulcer non-variceal gastrointestinal bleeding--a pilot study in Taiwan.;Chang;Hepatogastroenterology,2002

5. Endoscopic treatment of major bleeding from advanced gastroduodenal malignant lesions.;Loftus;Mayo Clin Proc,1994

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