Mild therapeutic hypothermia reduces ischemia-reperfusion injury following Zone 1 REBOA in a swine hemorrhagic shock model

Author:

Yang Zhao1,Jianxin Gao2,Chengcheng Li1,Guogeng Song3,Yi Shan4

Affiliation:

1. Department of Emergency Medicine, School of Medicine, South China University of Technology, Guangzhou 510006, China; Department of Emergency Medicine, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing 100048, China

2. Department of Emergency Medicine, The First Medical Center of PLA General Hospital of Beijing, Beijing 100853, China

3. Department of Emergency Medicine, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing 100048, China

4. Department of Emergency Medicine, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing 100048, China; Department of Emergency Medicine, School of Medicine, South China University of Technology, Guangzhou 510006, China

Abstract

ABSTRACT Background Resuscitative balloon occlusion of the aorta (REBOA) is an endovascular hemostasis method used for the management of traumatic abdominal and pelvic hemorrhages. However, REBOA-associated ischemia-reperfusion injury (IRI) complication limits its blocking time. We hypothesized that mild therapeutic hypothermia (TH) would relieve IRI caused by prolonged zone 1 REBOA. Methods Ten pigs were anesthetized, intubated, and subsequently struck with the experimental sliding-chamber ballistic gun to inflict liver damage. Animals were randomized to hypothermia (60 min of Zone 1 REBOA with external cooling for 180 min, n = 5) or control (60 min of Zone 1 REBOA with no external cooling, n = 5). Physiological and laboratory parameters were monitored and assessed. Distal organs were obtained for histologic analysis. Results At 180 min, compared with the control, the hypothermia animals exhibited significantly increased pH and significantly reduced lactate (Lac), hemoglobin (Hb) and hematocrit (Hct) (all p < 0.05). The change of Lac from 0 to 180 min in hypothermia animals was less than that in the control (p = 0.02). The total bleeding in the control group was significantly less than the hypothermia (p < 0.01). In the hypothermia group, PT at 120 and 180 min was significantly longer than that at baseline (all p < 0.05). Compared with the control, animals in hypothermia group showed slighter pathological injury of the distal organs and significantly lower overall injury score (all p < 0.05). Conclusions Mild TH during prolonged Zone 1 REBOA offered extraordinary distal organ preservation, and decreased metabolic acidosis.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.7亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2025 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3