Effects of hyperbaric oxygen therapy on intestinal ischemia-reperfusion and its mechanism

Abstract

Abstract Ischemia can cause reversible or irreversible cell or tissue damage, and reperfusion after ischemia not only has no therapeutic effect, but also aggravates cell damage. Notably, gut tissue is highly susceptible to ischemia-reperfusion injury under many adverse health conditions. Intestinal ischemia-reperfusion (IIR) is an important pathophysiological process in critical clinical diseases. Therefore, it is necessary to identify better therapeutic methods for relieving intestinal ischemia and hypoxia. Hyperbaric oxygenation (HBO) refers to the intermittent inhalation of 100% oxygen in an environment greater than 1 atmosphere pressure, which can better increase the oxygen level in the tissue, and change the inflammatory pathway. Currently, it can have a positive effect on hypoxia and ischemic diseases. Related studies have suggested that hyperbaric oxygen can significantly reduce ischemia-hypoxic injury to the brain, spinal cord, kidney and myocardium. This paper reviews the pathogenesis of ischemia-reperfusion and the current treatment measures, and further points out that hyperbaric oxygen has a better effect in ischemia-reperfusion. We found that not only improved hypoxia, but also regulated ischemia-reperfusion-induced injury in a certain way. From the perspective of clinical application, these changes and the application of hyperbaric oxygen therapyhave important implications for treatment, especially intestinal ischemia-reperfusion.