Affiliation:
1. Service of Pulmonology, Hospital Clínico Universitario de Santiago de Compostela
2. Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS)
3. School of Medicine, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
Abstract
Purpose of review
The incidence of bacterial respiratory tract infections is growing. In a context of increasing antibiotic resistance and lack of new classes of antibiotics, inhaled antibiotics emerge as a promising therapeutic strategy. Although they are generally used for cystic fibrosis, their use in other conditions is becoming more frequent, including no-cystic fibrosis bronchiectasis, pneumonia and mycobacterial infections.
Recent findings
Inhaled antibiotics exert beneficial microbiological effects in bronchiectasis and chronic bronchial infection. In nosocomial and ventilator-associated pneumonia, aerosolized antibiotics improve cure rates and bacterial eradication. In refractory Mycobacterium avium complex infections, amikacin liposome inhalation suspension is more effective in achieving long-lasting sputum conversion. In relation to biological inhaled antibiotics (antimicrobial peptides, interfering RNA and bacteriophages), currently in development, there is no still enough evidence that support their use in clinical practice.
Summary
The effective antimicrobiological activity of inhaled antibiotics, added to their potential to overcoming resistances to systemic antibiotics, make inhaled antibiotics a plausible alternative.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Pulmonary and Respiratory Medicine
Cited by
1 articles.
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