Reduced Plasma BDNF Levels in Normal Tension Glaucoma Compared to Open Angle Glaucoma

Author:

Sato Kota12ORCID,Takada Naoko1,Fujioka Amane1,Himori Noriko13,Yokoyama Yu1,Tsuda Satoru1,Omodaka Kazuko1,Kirihara Tomoko4,Ishikawa Makoto5,Kunikata Hiroshi1,Nakazawa Toru1256

Affiliation:

1. Ophthalmology

2. Advanced Ophthalmic Medicine

3. Department of Aging Vision Healthcare, Tohoku University Graduate School of Biomedical Engineering, Miyagi

4. Ophthalmic Innovation Center, Santen Pharmaceutical Co., Ltd, Osaka, Japan

5. Ophthalmic Imaging and Information Analytics

6. Retinal Disease Control, Tohoku University Graduate School of Medicine, Miyagi, Japan

Abstract

Précis: The study suggests that a low level of systemic BDNF may contribute to the pathogenesis of glaucoma in an IOP-independent manner. Aims: To evaluate differences in systemic brain-derived neurotrophic factor (BDNF) levels between primary open angle glaucoma (POAG) patients and normal tension glaucoma (NTG) patients. Methods: This study collected blood samples from 260 NTG patients, 220 age-matched POAG patients, and 120 age-matched cataract patients (as controls). BDNF levels were measured with an antibody-conjugated bead assay system (Luminex). Results: We found that plasma BDNF levels in the NTG group were significantly lower than in the POAG and cataract control groups. There was no significant difference between the POAG and cataract groups. Conclusion: This result suggests that a low level of systemic BDNF may contribute to the pathogenesis of glaucoma in an IOP-independent manner.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Ophthalmology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3