Conflicts hurt: social stress predicts elevated pain and sadness after mild inflammatory increases

Author:

Madison Annelise A.12ORCID,Renna Megan3ORCID,Andridge Rebecca4ORCID,Peng Juan4,Shrout M. Rosie5ORCID,Sheridan John16ORCID,Lustberg Maryam7ORCID,Ramaswamy Bhuvaneswari89ORCID,Wesolowski Robert89ORCID,Williams Nicole O.89,Noonan Anne M.89ORCID,Reinbolt Raquel E.89ORCID,Stover Daniel G.89ORCID,Cherian Mathew A.89ORCID,Malarkey William B.8ORCID,Kiecolt-Glaser Janice K.110ORCID

Affiliation:

1. Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, United States

2. Department of Psychology, The Ohio State University, Columbus, OH, United States

3. School of Psychology, University of Southern Mississippi, Hattiesburg, MS, United States

4. Division of Biostatistics, The Ohio State University, Columbus, OH, United States

5. College of Health and Human Sciences, Purdue University, West Lafayette, IN, United States

6. Division of Biosciences, The Ohio State University College of Dentistry, Columbus, OH, United States

7. Yale School of Medicine, New Haven, CT, United States

8. Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, United States

9. Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, United States

10. Department of Psychiatry and Behavioral Health, The Ohio State University College of Medicine, Columbus, OH, United States

Abstract

AbstractIndividuals respond differently to inflammation. Pain, sadness, and fatigue are common correlates of inflammation among breast cancer survivors. Stress may predict response intensity. This study tested whether breast cancer survivors with greater exposure to acute or chronic social or nonsocial stress had larger increases in pain, sadness, and fatigue during an acute inflammatory response. In total, 156 postmenopausal breast cancer survivors (ages 36-78 years, stage I-IIIA, 1-9 years posttreatment) were randomized to either a typhoid vaccine/saline placebo or the placebo/vaccine sequence, which they received at 2 separate visits at least 1 month apart. Survivors had their blood drawn every 90 minutes for the next 8 hours postinjection to assess levels of interleukin-6 and interleukin-1 receptor antagonist (IL-1Ra). Shortly after each blood draw, they rated their current levels of pain, sadness, and fatigue. Women also completed the Test of Negative Social Exchange to assess chronic social stress and the Trier Inventory of Chronic Stressors screen to index chronic general stress. At each visit, a trained experimenter administered the Daily Inventory of Stressful Events to assess social and nonsocial stress exposure within the past 24 hours. After statistical adjustment for relevant demographic and behavioral covariates, the most consistent results were that survivors who reported more chronic social stress reported more pain and sadness in response to IL-1Ra increases. Frequent and ongoing social stress may sensitize the nervous system to the effects of inflammation, with potential implications for chronic pain and depression risk among breast cancer survivors.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Anesthesiology and Pain Medicine,Neurology (clinical),Neurology

Reference77 articles.

1. Risk factors, prevalence, and course of severe fatigue after breast cancer treatment: a meta-analysis involving 12 327 breast cancer survivors;Abrahams;Ann Oncol,2016

2. The daily inventory of stressful events: an interview-based approach for measuring daily stressors;Almeida;Assessment,2002

3. Using generalized estimating equations for longitudinal data analysis;Ballinger;Organ Res Methods,2004

4. Passage of cytokines across the blood-brain barrier;Banks;Neuroimmunomodulation,1995

5. Outcome measures of depression. In Strupp HH, Horowitz LM, Lambert MJ, (Eds.). Measuring patient changes in mood, anxiety, and personality disorders: Toward a core battery. American Psychological Association;Basco,1997

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3