Preclinical Development of New Drugs that Enhance Thyroid Hormone Metabolism and Clearance: Inadequacy of Using Rats as an Animal Model for Predicting Human Risks in an IND and NDA-Reference-Cited by-同舟云学术

Preclinical Development of New Drugs that Enhance Thyroid Hormone Metabolism and Clearance: Inadequacy of Using Rats as an Animal Model for Predicting Human Risks in an IND and NDA

Published:2006-03 Issue:2 Volume:13 Page:141-144
ISSN:1075-2765
Container-title:American Journal of Therapeutics
language:en
Short-container-title:American Journal of Therapeutics

Author:

Wu Kuei-Meng,Farrelly James G.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference19 articles.

1. Carcinogenicity Testing and the Evaluation of Regulatory Requirements for Pharmaceuticals

2. The Significance of Hepatic Microsomal Enzyme Induction and Altered Thyroid Function in Rats: Implications for Thyroid Gland Neoplasia

3. Human UDP-Glucuronosyltransferases: Metabolism, Expression, and Disease

4. Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter.

5. Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methyl glutaryl CoA reductase, on drug-metabolizing enzymes in rats

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