Systematic review of topical interventions for the management of pain in chronic wounds

Author:

Ffrench Cathal123ORCID,Finn David2345,Velligna Akke6,Ivory John178,Healy Catherine2345,Butler Karen17,Sezgin Duygu17,Carr Peter1,Probst Sebastian91011,McLoughlin Aonghus71213,Arshad Sundus12,McIntosh Caroline714,Gethin Georgina127910

Affiliation:

1. School of Nursing and Midwifery, University of Galway, Galway, Ireland

2. CÚRAM, SFI Research Centre for Medical Devices, Galway, Ireland

3. Centre for Pain Research, University of Galway, Galway, Ireland

4. Pharmacology and Therapeutics, School of Medicine, University of Galway, Galway, Ireland

5. Galway Neuroscience Centre, University of Galway, Galway, Ireland

6. School of Public Health, Physiotherapy and Sports Science, University College Dublin (UCD), Dublin, Ireland

7. Alliance for Research and Innovation in Wounds, University of Galway, Galway, Ireland

8. Irish Research Council (IRC), Dublin, Ireland

9. Geneva School of Health Science, HES-SO University of Applied Sciences and Arts, Western Switzerland, Geneva, Switzerland,

10. Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, Australia

11. Care Directorate, University Hospital Geneva, Geneva, Switzerland

12. Department of Medicine, University of Galway, Galway, Ireland

13. Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospital, Galway, Ireland

14. Discipline of Podiatric Medicine, School of Health Science, University of Galway, Galway, Ireland

Abstract

Abstract Chronic wounds adversely affect quality of life. Pain is associated with chronic wounds, and its impact can vary according to wound aetiology, condition, and patient factors. This systematic review examined the effectiveness of topical interventions in the management chronic wound–related pain guided by PRISMA recommendations of randomised controlled trials (RCTs) where pain reduction is the primary outcome. Inclusion criteria were adults (older than 18 years) with chronic venous, arterial, diabetic, or pressure ulcers where pain has been managed through topical administration of pharmacological/nonpharmacological agents. Searches were conducted in Ovid Embase, Ovid MEDLINE, EBSCOhost, CINAHL, CENTRAL, PubMed, Web of Science, and Scopus. Studies were screened for eligibility; risk of bias and data were extracted by 2 independent assessors. Searches retrieved 10,327 titles and abstracts (7760 after deduplication). Nine full texts (1323 participants) examining ibuprofen (n = 4), morphine (n = 2), BWD + PHMB [polihexanide-containing biocellulose wound dressing] (n = 1), and EMLA (n = 2) were included. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Meta-analysis was not possible, but initial exploration suggests improved outcomes (reduced pain) for ibuprofen when compared with controls. Two studies involving morphine showed conflicting findings. Included studies often had small samples, and considering confounding factors (eg, comorbidities), the results should be interpreted with caution. Review of included studies suggests that topical interventions may provide pain relief in individuals with chronic wounds. Further adequately powered RCTs are recommended to assess the efficacy of topical interventions for the management of chronic wound–related pain.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Anesthesiology and Pain Medicine

Reference35 articles.

1. Topical analgesics in the management of acute and chronic pain;Argoff;Mayo Clinic Proc,2013

2. Topical morphine gel in the treatment of painful leg ulcers, a double‐blind, placebo-controlled clinical trial: a pilot study;Bastami;Int Wound J,2012

3. Measuring well‐being rather than the absence of distress symptoms: a comparison of the SF-36 mental health subscale and the WHO‐Five well‐being scale;Bech;Int J Methods Psychiatr Res,2003

4. Pain management and wound care;Bechert;J Am Coll Certifi Wound Spec,2009

5. Topical agents or dressings for pain in venous leg ulcers;Briggs;Cochrane Database Syst Rev,2012

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