Inflammation and Fibrosis in Orbital Inflammatory Disease: A Histopathologic Analysis-Reference-Cited by-同舟云学术

Inflammation and Fibrosis in Orbital Inflammatory Disease: A Histopathologic Analysis

Published:2023-06-06 Issue:6 Volume:39 Page:588-593
ISSN:0740-9303
Container-title:Ophthalmic Plastic & Reconstructive Surgery
language:en
Short-container-title:

Author:

Verma Rohan¹²,Chen Allison J.³,Choi Dongseok⁴⁵,Wilson David J.²,Grossniklaus Hans E.⁶,Dailey Roger A.¹²,Ng John D.¹²,Steele Eric A.¹²,Planck Stephen R.²⁷,Czyz Craig N.⁸,Korn Bobby S.³⁹,Kikkawa Don O.³⁹,Foster Jill A.¹⁰,Kazim Michael¹¹,Harris Gerald J.¹²,Edward Deepak P.¹³¹⁴,Al Maktabi Azza¹⁴,Rosenbaum James T.²⁴⁷¹⁵

Affiliation:

1. Oculofacial Plastic and Reconstructive Surgery, Casey Aesthetic Facial Surgery Center, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, U.S.A.

2. Ophthalmology Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, U.S.A.

3. Oculofacial Plastic and Reconstructive Surgery, University of California San Diego- Shiley Eye Institute and Viterbi Family Department of Ophthalmology, La Jolla, California, U.S.A.

4. Department of Medicine, Oregon Health & Science University, Portland, Oregon, U.S.A.

5. OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, Oregon, U.S.A.

6. Ophthalmology, Emory Eye Center, Emory University, Atlanta, Georgia, U.S.A.

7. Ophthalmology Devers Eye Institute, Legacy Health Systems, Portland, Oregon, U.S.A.

8. Oculofacial Plastic and Reconstructive Surgery, Ohio University/OhioHealth, Columbus, Ohio, U.S.A.

9. Plastic Surgery, University of California San Diego, La Jolla, California, U.S.A.

10. Oculofacial Plastic and Reconstructive Surgery, Ophthalmic Surgeons and Consultants of Ohio, Columbus, Ohio, U.S.A.

11. Oculofacial Plastic and Reconstructive Surgery, Edward S Harkness Eye Institute, Columbia University, New York, New York, U.S.A.

12. Oculofacial Plastic and Reconstructive Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.

13. Ophthalmology, University of Illinois College of Medicine, Chicago, Illinois, U.S.A.

14. King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia

15. Corvus Pharmaceuticals Inc., Burlingame, CA, U.S.A.

Abstract

Purpose: The purpose of this study was to compare the histopathologic inflammation and fibrosis of orbital adipose tissue in orbital inflammatory disease (OID) specimens. Methods: In this retrospective cohort study, inflammation, and fibrosis in orbital adipose tissue from patients with thyroid-associated orbitopathy (TAO), granulomatosis with polyangiitis (GPA), sarcoidosis, nonspecific orbital inflammation (NSOI), and healthy controls were scored by 2 masked ocular pathologists. Both categories were scored on a scale of 0 to 3 with scoring criteria based on the percentage of specimens containing inflammation or fibrosis, respectively. Tissue specimens were collected from oculoplastic surgeons at 8 international centers representing 4 countries. Seventy-four specimens were included: 25 with TAO, 6 with orbital GPA, 7 with orbital sarcoidosis, 24 with NSOI, and 12 healthy controls. Results: The mean inflammation and fibrosis scores for healthy controls were 0.0 and 1.1, respectively. Orbital inflammatory disease groups’ inflammation (I) and fibrosis (F) scores, formatted [I, F] with respective p-values when compared to controls, were: TAO [0.2, 1.4] (p = 1, 1), GPA [1.9, 2.6] (p = 0.003, 0.009), sarcoidosis [2.4, 1.9] (p = 0.001, 0.023), and NSOI [1.3, 1.8] (p ≤ 0.001, 0.018). Sarcoidosis had the highest mean inflammation score. The pairwise analysis demonstrated that sarcoidosis had a significantly higher mean inflammation score than NSOI (p = 0.036) and TAO (p < 0.0001), but no difference when compared to GPA. GPA had the highest mean fibrosis score, with pairwise analysis demonstrating a significantly higher mean fibrosis score than TAO (p = 0.048). Conclusions: Mean inflammation and fibrosis scores in TAO orbital adipose tissue samples did not differ from healthy controls. In contrast, the more “intense” inflammatory diseases such as GPA, sarcoidosis, and NSOI did demonstrate higher histopathologic inflammation and fibrosis. This has implications in prognosis, therapeutic selection, and response monitoring in orbital inflammatory disease.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Ophthalmology,General Medicine,Surgery

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