Current approaches to overcome recurrent focal segmental glomerulosclerosis after kidney transplantation

Author:

Ahmad Syeda Behjat1,Peleg Yonatan2,Ahn Wooin3

Affiliation:

1. University of Pittsburgh School of Medicine, Division of Renal-Electrolyte, Pittsburgh, Pennsylvania

2. Northwestern University Feinberg School of Medicine, Division of Nephrology and Hypertension, Chicago, Illinois

3. Oregon Health & Science University School of Medicine, Division of Nephrology and Hypertension, Portland, Oregon, USA

Abstract

Purpose of review Recurrent focal segmental glomerulosclerosis (FSGS) presents with nephrotic syndrome shortly after kidney transplantation. This review will overview the role of circulating permeability factors in disease pathogenesis and treatment options for recurrent FSGS. Recent findings Novel circulating permeability factors have been identified in serum samples. Current research is focused on detection of permeability factors as a marker of treatment response. Furthermore, novel monoclonal antibodies are being utilized to further induce remission. Summary Posttransplant recurrent FSGS can have a deleterious effect on allograft. Early detection of disease recurrence with prompt treatment is optimal for clinical remission. Plasmapheresis with anti-B cell therapy is considered the mainstay of treatment. Newer B cell therapies and detection of circulating factors in serum may help in providing targeted treatment in a subset of patients.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Nephrology,Internal Medicine

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