1. 1Harvard Medical School, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Boston, Massachusetts; Departments of Physiology and Biophysics, and Biomedical Engineering, Boston University, Boston, Massachusetts; Department of Cardiac Anesthesiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Charité Universitätsmedizin, Berlin, Germany.