Drug Titration Paradox: An Emerging Concept in Clinical Pharmacology-Reference-Cited by-同舟云学术

Drug Titration Paradox: An Emerging Concept in Clinical Pharmacology

Published:2023-08-31 Issue:1 Volume:140 Page:157-163
ISSN:0003-3022
Container-title:Anesthesiology
language:en
Short-container-title:

Author:

Minto Charles F.¹,Egan Talmage D.²,Schnider Thomas W.³^ORCID

Affiliation:

1. 1Department of Anesthesia, North Shore Private Hospital, Sydney, Australia.

2. 2Department of Anesthesiology, University of Utah, Salt Lake City, Utah.

3. 3Department of anesthesia, Intensive Care, Emergency and Pain Medicine, Kantonsspital, St. Gallen, Switzerland.

Abstract

When anesthesiologists titrate doses to achieve desired effects, a titration paradox emerges resulting in increased drug doses which correlate with decreased effect. This challenges traditional pharmacologic understanding and requires careful analysis of potential confounding factors.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Anesthesiology and Pain Medicine

Link

https://pubs.asahq.org/anesthesiology/article-pdf/140/1/157/698610/20240100.0-00023.pdf

Reference22 articles.

1. Getting the dose right: Anaesthetic drug delivery and the posological sweet spot.;Kuck;Br J Anaesth,2017

2. Relationship between propofol target concentrations, bispectral index, and patient covariates during anesthesia.;Schnider;Anesth Analg,2021

3. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.;Schnider;Anesthesiology,1998

4. The influence of age on propofol pharmacodynamics.;Schnider;Anesthesiology,1999

5. Retrospective comparison of Eleveld, Marsh, and Schnider propofol pharmacokinetic models in 50 patients.;Huppe;Br J Anaesth,2020

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Steady-state trumps accuracy: target-controlled infusion as a gain switch;British Journal of Anaesthesia;2024-08

2. Data-driven identification and comparison of full multivariable models for propofol–remifentanil induced general anesthesia;Journal of Process Control;2024-07

3. Paradigm shifts in clinical pharmacology: things are not always as they seem;Current Opinion in Anaesthesiology;2024-06-30

4. The drug titration paradox: a control engineering perspective;Current Opinion in Anaesthesiology;2024-05-30

5. Drug Titration Paradox: Comment;Anesthesiology;2024-05-20