1. From the Department of Drug Discovery, Galleon Pharmaceuticals, Inc., Horsham, Pennsylvania (F.J.G., S.D., S.M.B., R.G., C.I., A.K., S.P., V.P., D.R., R.W., J.C.M., D.E.M.); Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania (T.H.); and Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina (R.L.W., M.R.V.S.).