Mixed reality-supported near-infrared photoimmunotherapy for oropharyngeal cancer: a case report-Reference-Cited by-同舟云学术

Mixed reality-supported near-infrared photoimmunotherapy for oropharyngeal cancer: a case report

Published:2024-08-07 Issue:9 Volume:86 Page:5551-5556
ISSN:2049-0801
Container-title:Annals of Medicine & Surgery
language:en
Short-container-title:

Author:

Okada Ryuhei¹,Ito Taku²,Kawabe Hiroaki¹,Tsutsumi Takeshi²,Asakage Takahiro¹

Affiliation:

1. Department of Head and Neck Surgery, Tokyo Medical and Dental University

2. Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan

Abstract

Introduction and importance: Near-infrared photoimmunotherapy (NIR-PIT, Alluminox) uses an antibody-photoabsorber conjugate and light excitation, requiring precise illumination. Mixed reality (MR) technology can enhance medical procedures through advanced visualization and planning. Case presentation: An 86-year-old man with recurrent oropharyngeal cancer and right cervical metastasis received NIR-PIT. Three-dimensional models from computed tomography (CT) and FDG-PET/CT images were used as holograms on a head-mounted display (HMD) for precise light targeting. Clinical discussion: HMD-MR technology was utilized for preoperative simulation and guided ideal light direction during surgery. This improved the effectiveness of NIR-PIT. Conclusion: Three months post-treatment, no residual lesion was observed, demonstrating the utility of HMD-MR technology in optimizing NIR-PIT outcomes.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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