Neurogenomics in Africa: current state, challenges, opportunities, and recommendation

Abstract

Neurological diseases are becoming more common in Africa. Current estimates indicate that Africa has a significant burden of neurological illnesses, though it is unclear what fraction of the burden may be linked to genetic transmission. In recent years, there has been a significant expansion in the knowledge of the genetic basis of neurological illnesses. This has been made possible mainly by the positional cloning research paradigm, which uses linkage studies to pinpoint specific genes on chromosomes and targeted screening of Mendelian neurological illnesses to identify the causative genes. However, there is currently very little and unequal geographic knowledge about neurogenetics in African people. The lack of collaboration between academics studying neurogenomics and bioinformatics contributes to the scarcity of large-scale neurogenomic investigations in Africa. The primary cause is a shortage of funding from the African government for clinical researchers; this has resulted in heterogeneity in research collaboration in the region as African researchers work more closely with researchers outside the region due to pulling factors of standardized laboratory resources and adequate funding. Therefore, adequate funding is required to elevate researchers’ morale and give them the resources they need for their neurogenomic and bioinformatics studies. For Africa to fully benefit from this significant research area, substantial and sustainable financial investments in the training of scientists and clinicians will be required.