Remyelination in multiple sclerosis, along with its immunology and association with gut dysbiosis, lifestyle, and environmental factors

Author:

Prajjwal Priyadarshi1,Inban Pugazhendi2,Natarajan Balaganesh3,Gadam Srikanth4,Marsool Mohammed D.M.5,Tariq Halla6,Paras Paras7,Vora Neel8,Al-Aish Sandra T.9,Marsool Ali D.M.5,Amir Hussin Omniat10

Affiliation:

1. Bharati Vidyapeeth University Medical College, Pune

2. Government Medical College Omandurar, Chennai, Tamil Nadu

3. St. George’s University School of Medicine, University Centre Grenada, West Indies, Grenada

4. Postdoctoral Research Fellow, Mayo Clinic, USA

5. University of Baghdad, Al-Kindy College of Medicine

6. Multan Medical and Dental College, Pakistan

7. Government Medical College, Patiala, Punjab

8. BJ Medical College, Ahmedabad, India

9. University of Baghdad, College of Medicine, Baghdad, Iraq

10. Al-Manhal Academy, Khartoum, Sudan

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease that damages the myelin sheath around the axons of the central nervous system. While there are periods of inflammation and remyelination in MS, the latter can sometimes be insufficient and lead to the formation of lesions in the brain and spinal cord. Environmental factors such as vitamin D deficiency, viral or bacterial infections, tobacco smoking, and anxiety have been shown to play a role in the development of MS. Dysbiosis, where the composition of the microbiome changes, may also be involved in the pathogenesis of MS by affecting the gut’s microbial population and negatively impacting the integrity of the epithelia. While the cause of MS remains unknown, genetic susceptibility, and immunological dysregulation are believed to play a key role in the development of the disease. Further research is needed to fully understand the complex interplay between genetic, environmental, and microbial factors in the pathogenesis of MS.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine,Surgery

Reference79 articles.

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3