Contralateral differences in ankle SBP and pulse wave velocity: associations with incident heart failure and mortality

Abstract

Background: Contralateral differences in brachial SBP are indicative of underlaying cardiovascular issues. Objectives: To examine the association of contralateral differences in ankle SBP, brachial-ankle pulse wave velocity (baPWV), and heart-ankle pulse wave velocity (haPWV) with incident heart failure and all-cause and cardiovascular mortality. Methods: Cox proportional-hazards models were used to calculate hazard ratios and 95% confidence intervals (95% CIs) in 5077 participants (75 ± 5 years) of the Atherosclerosis Risk in Communities study. Results: Over a mean follow-up of 7.5 ± 2.2 years, there were 457 heart failure events, 1275 all-cause and 363 cardiovascular deaths. Interankle SBP difference of at least 10 mmHg [hazard ratio = 1.12; confidence interval (CI) 1.00–1.28], at least 15 mmHg (hazard ratio = 1.21; CI 1.03–1.43), contralateral difference in baPWV more than 240 cm/s (hazard ratio = 1.22; CI 1.02–1.46), and haPWV more than 80 cm/s (hazard ratio = 1.24; CI 1.04–1.48) were each independently associated with all-cause mortality after adjustment for confounders. Contralateral differences in ankle SBP of at least 15 mmHg (hazard ratio = 1.56; CI 1.17–2.09), and haPWV more than 80 cm/s (hazard ratio = 1.42; CI 1.03–1.96) were both independently associated with cardiovascular mortality. Unadjusted analysis revealed that those with contralateral differences in ankle SBP of at least 10 and at least 15 mmHg, baPWV more than 240, and haPWV more than 80 cm/s had higher risks of heart failure (all P < 0.05). Conclusion: These results underscore the significance of evaluating contralateral differences in ankle SBP and PWV as potential markers of increased mortality risk among older adults.