Association Between Whole Blood Transfusion and Mortality Among Injured Pediatric Patients

Abstract

Objective: To assess the association between whole blood (WB) and mortality among injured children who received immediate blood transfusion. Background: The use of WB for transfusion therapy in trauma has been revisited, and recent studies have reported an association between WB and improved survival among adults. However, evidence of a similar association lacks in children. Methods: We performed a retrospective cohort study from the ACS-TQIP between 2020 and 2021. Patients were aged ≤16 years and had immediate blood transfusion within 4 hours of hospital arrival. Survival at 24 hours and 30 days were compared after creating 1:1 propensity-score matched cohorts, matching for demographics, injury type, vital signs on admission, trauma severity scores, hemorrhage control procedures, hospital characteristics, and the need for massive transfusion. Results: A total of 2,729 patients were eligible for analysis. The median age was 14 years (interquartile range: 8-16 y); 1,862 (68.2%) patients were male; and 1,207 (44.2%) patients were White. A total of 319 (11.7%) patients received WB. After a 1:1-ratio propensity score matching, 318 matched pairs were compared. WB transfusion was associated with improved survival at 24 hours, demonstrating a 42% lower risk of mortality (hazard ratio [HR], 0.58; 95% confidence interval [CI], 0.34–0.98; P=0.042) Similarly, the survival benefit associated with WB transfusion remained consistent at 30 days (HR, 0.65; 95% CI, 0.46–0.90; P=0.011). Conclusions: The use of WB was associated with improved survival among injured pediatric patients requiring immediate transfusion.