Ganoderma lucidum spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis

Author:

Lian Shu1,Li Wulin2,Zhong Chunlian1,Li Ye3,Wu Changhui3,Zhang Kun3,Lin Jiangfei1,Wang Weiyu14,Katanaev Vladimir5,Xie Xiaodong1,Jia Lee12

Affiliation:

1. Fujian-Taiwan-Hongkong-Macao Science and Technology Cooperation Base of Intelligent Pharmaceutics, Institute of Oceanography, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian, China

2. Institute of Chemisty, Fuzhou University, Fuzhou, Fujian, China

3. Fujian Xianzhilou Biological and Technology Co., Ltd., Fuzhou, China

4. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China

5. Translational Research Center in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland

Abstract

Background: Ganoderma lucidum (G. lucidum) is a traditional Chinese herbal medicine that has shown potential as an alternative adjuvant therapy for cancer patients. However, the mechanisms and adjuvant therapeutic effects of G. lucidum in cancer treatment remain unclear. Methods: In this work, G. lucidum spore oil (GanoOil), a newly developed oily G. lucidum spore extract was used to investigate the mechanisms and adjuvant therapeutic effects of GanoOil in conjunction with the chemotherapeutic drug cyclophosphamide (CTX) for preventing breast cancer metastasis. Results: In the model of lung metastasis, orally administered GanoOil increased the population of CD8 + T cells and IL-6 cytokine levels in mouse blood, while also enhancing the activity of natural killer cells in the spleen. Furthermore, the combination of GanoOil and CTX effectively suppressed the lung metastasis of circulating breast cancer cells, alleviated CTX-induced weight loss, and reduced the ratio of lung and spleen weight to body weight in mice. Moreover, high concentrations of GanoOil exhibited no significant toxicity or side effects in both in vitro and in vivo experiments. Conclusion: In conclusion, GanoOil is a safe drug that can enhance immune activity in mice to achieve therapeutic effects on cancer, and can also synergistically inhibit tumor metastasis with CTX.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

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1. Cervical cancer: Part I human papilloma virus vaccination in Taiwan;Taiwanese Journal of Obstetrics and Gynecology;2024-05

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