Clinical standardization for the detection of hemispheric dominance for steady-state auditory evoked fields in normal hearing

Author:

Wang Mao-Che123,Chi Tai-Shih4,Shiao An-Suey5,Li Lieber Po-Hung25678,Hsieh Jen-Chuen891011

Affiliation:

1. Department of Otolaryngology Head Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC

2. Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC

3. Department of Otolaryngology Head Neck Surgery, Taipei City Hospital, Taipei, Taiwan, ROC

4. Department of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, ROC

5. Department of Otolaryngology, Cheng Hsin General Hospital, Taipei, Taiwan, ROC

6. Institute of Brain Science, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC

7. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC

8. Integrated Brain Research Unit, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC

9. Department of Biological Science and Technology, College of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, ROC

10. Center for Intelligent Drug Systems and Smart Bio-devices, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, ROC

11. Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC

Abstract

Background: Steady-state auditory evoked responses (SSAERs) are promising indicators of major auditory function. The improvement in accessibility in the clinical setting depends on the standardization and definition of the characteristics of SSAERs. There have been some insights into the changes in the interhemispheric dominance of SSAERs in some clinical entities. However, the hemispheric asymmetry of SSAERs in healthy controls remains inconclusive. Methods: Twelve right-handed healthy volunteers with normal hearing were recruited. Steady-state auditory evoked fields (SSAEFs) were measured binaurally using magnetoencephalography (MEG) under pure-tone auditory stimuli at 1000 Hz with an amplitude modulation frequency of 43 Hz. The laterality index, based on the ratio of SSAEF strength over the right hemisphere to that over the left hemisphere, was also analyzed. Results: The SSAEFs source was localized bilaterally on the superior temporal plane, with an orientation centripetal to the auditory cortex. The laterality index ranged from 1.1 to 2.3, and there were no sex differences. In all subjects, the strength of the SSAEFs was significantly weaker in the left hemisphere than in the right hemisphere (p = 0.014). Conclusion: Right-sided dominance of the SSAEFs was verified in subjects with normal hearing. Acoustic sources clinically available in audiometric tests were used as stimuli. Such a simplification of parameters would be helpful for the standardization of precise production and the definition of the characteristics of SSAERs. Because MEG is still not easily accessible clinically, further studies using electroencephalography with larger sample sizes are necessary to address these issues.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

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