The role of phytoandrogens for benign prostatic hyperplasia treatment

Author:

Wu Yaoxin123,Wichai Nuttapong4,Yang Xiaohua15,Ma Yaxuan23,Suo Tongchuan56,Miao Lin1235

Affiliation:

1. Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin Health Industry Park, Jinghai, Tianjin, China

2. Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin Health Industry Park, Jinghai, Tianjin, China

3. Key Laboratory of Pharmacology of Traditional Chinese Medical Formula, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin Health Industry Park, Jinghai, Tianjin, China

4. Faculty of Pharmacy, Mahasarakham University, Kantharawichai, Maha Sarakham Province, Thailand

5. Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China

6. College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China

Abstract

Benign prostatic hyperplasia (BPH) is a common urological condition in aging men. High levels of androgens, including testosterone (T) and dihydrotestosterone (DHT), are closely associated with BPH occurrence and development. Currently, the main clinical drugs used for BPH treatment are 5α-reductase inhibitors and α-receptor blockers, both of which aim to decrease abnormal androgenic signaling while having several unignored side effects. Recently, various natural herbs, such as tonifying yang traditional Chinese medicine (TCM), have been found to have androgenic activities, some of which are also effective for BPH treatment. Here, we review the androgenic activities of phytoandrogens, together with their therapeutic effects in BPH, and summarize the mechanisms involved, providing evidence that such herbs serve as selective androgen receptor modulators. Graphical abstract: http://links.lww.com/AHM/A46

Publisher

Ovid Technologies (Wolters Kluwer Health)

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