Generation of a humanized anti-glypican 3 antibody by CDR grafting and stability optimization

Author:

Nakano Kiyotaka,Ishiguro Takahiro,Konishi Hiroko,Tanaka Megumi,Sugimoto Masamichi,Sugo Izumi,Igawa Tomoyuki,Tsunoda Hiroyuki,Kinoshita Yasuko,Habu Kiyoshi,Orita Tetsuro,Tsuchiya Masayuki,Hattori Kunihiro,Yamada-Okabe Hisafumi

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cancer Research,Pharmacology (medical),Pharmacology,Oncology

Reference37 articles.

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2. Mutations in GPC3, a glypican gene, cause the Simpson–Golabi–Behmel overgrowth syndrome;Pilia;Nat Genet,1996

3. Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson–Golabi–Behmel syndrome;Cano-Gauci;J Cell Biol,1999

4. Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling;Capurro;Cancer Res,2005

5. Cloning and expression of a developmentally regulated transcript MXR7 in hepatocellular carcinoma: biological significance and temporospatial distribution;Hsu;Cancer Res,1997

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