1. * Resident, ∥ Professor, Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital and Karolinska Institutet. † Principal Scientist, Director, Target Biology, AstraZeneca Pharmaceuticals, Wilmington, Delaware. ‡ Senior Research Scientist, § Associate Professor, Molecular Pharmacology, AstraZeneca R&D, Södertälje, Sweden.