Affiliation:
1. Fellow.
2. Assistant Professor of Anesthesia.
Abstract
Background
To determine the effect of age on the dose-response relation and infusion requirement of cisatracurium besylate in pediatric patients, 32 infants (mean age, 0.7 yr; range, 0.3-1.0 yr) and 32 children (mean age, 4.9 yr; range, 3.1-9.6 yr) were studied during thiopentone-nitrous oxideoxygen-narcotic anesthesia.
Methods
Potency was determined using a single-dose (20, 26, 33, or 40 microg/kg) technique. Neuromuscular block was assessed by monitoring the electromyographic response of the adductor pollicis to supramaximal train-of-four stimulation of the ulnar nerve at 2 Hz.
Results
Least-squares linear regression analysis of the log-probit transformation of dose and maximal response yielded median effective dose (ED50) and 95% effective dose (ED95) values for infants (29+/-3 microg/kg and 43+/-9 microg/kg, respectively) that were similar to those for children (29+/-2 microg/kg and 47+/-7 microg/kg, respectively). The mean infusion rate necessary to maintain 90-99% neuromuscular block during the first hour in infants (1.9+/-0.4 microg x kg(-1) x min(-1); range: 1.3-2.5 microg x kg(-1) x min(-1)) was similar to that in children (2.0+/-0.5 microg x kg(-1) x min(-1); range: 1.3-2.9 microg x kg(-1) x min(-1)).
Conclusion
The authors conclude that cisatracurium is equipotent in infants and children when dose is referenced to body weight during balanced anesthesia.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Anesthesiology and Pain Medicine
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Neuromuscular Blockade;Pediatric Critical Care;2021
2. Neuromuscular Blocking Agents;Smith's Anesthesia for Infants and Children;2017
3. Perioperative care of infants with pyloric stenosis;Pediatric Anesthesia;2015-10-22
4. Neuromuscular Blockade;Pediatric Critical Care Study Guide;2011-12-16
5. Neuromuscular Blocking Agents;Pediatric Critical Care;2011