Affiliation:
1. Research Associate.
2. Professor of Anesthesiology.
3. Professor of Biophysics and Anaesthetics.
4. Sir Ivan Magill Professor of Anaesthetics, Departments of Anesthetics and Biological Sciences, Imperial College of Science, Technology and Medicine, London, United Kingdom.
5. Associate Professor of Anesthesiology, Department of Anesthesiology (Multidisciplinary Neuroprotection Laboratories), Duke University Medical Center.
Abstract
Background
Xenon has been shown to be neuroprotective in several models of in vitro and in vivo neuronal injury. However, its putative neuroprotective properties have not been evaluated in focal cerebral ischemia. The purpose of this study was to determine if xenon offers neuroprotection in a mouse model of middle cerebral artery occlusion.
Methods
C57BL/6 mice underwent 60 min of middle cerebral artery occlusion. The animals (n = 21 per group) were randomized to receive either 70% xenon + 30% O2, 70% N2O + 30% O2, or 35% xenon + 35% N2O + 30% O2. After 24 h, functional neurologic outcome (on three independent scales: four-point, general, and focal deficit scales) and cerebral infarct size were evaluated.
Results
The 70% xenon + 30% O2 group showed improved functional outcome (median [interquartile range], four-point scale: 2 [2], 70% xenon + 30% O2 versus 3 [2], 70% N2O + 30% O2, P = 0.0061; general deficit scale: 9 [6], 70% xenon + 30% O2 versus 10 [4], 70% N2O + 30% O2, P = 0.0346). Total cerebral infarct volumes were reduced in the 70% xenon + 30% O2 group compared with the 70% N2O + 30% O2 group (45 +/- 17 mm3 versus 59 +/- 11 mm3, respectively; P = 0.0009).
Conclusions
In this model of transient focal cerebral ischemia, xenon administration improved both functional and histologic outcome.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Anesthesiology and Pain Medicine
Cited by
145 articles.
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