INTRACELLULAR EXPRESSION IN PIG CELLS OF ANTI-??1,3GALACTOSYLTRANSFERASE SINGLE-CHAIN FV ANTIBODIES REDUCES GAL??1,3GAL EXPRESSION AND INHIBITS CYTOTOXICITY MEDIATED BY ANTI-GAL XENOANTIBODIES1
Author:
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Transplantation
Reference37 articles.
1. Interaction of the natural anti-Gal antibody with α-galactosyl epitopes: a major obstacle for xenotransplantation in humans
2. Simultaneous expression by porcine aorta endothelial cells of glycosphingolipids bearing the major epitope for human xenoreactive antibodies (Gal?1?3Gal), blood group H determinant andN-glycolylneuraminic acid
3. Characterization of porcine platelet glycoproteins recognized by human natural "anti-gal" antibodies
4. Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis
5. DOWN-REGULATION OF Gal??(1,3)Gal EXPRESSION BY ??1,2-FUCOSYLTRANSFERASE
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