RAPAMYCIN: CLINICAL RESULTS AND FUTURE OPPORTUNITIES1
Author:
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Transplantation
Reference94 articles.
1. Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression
2. Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface
3. Atomic Structure of FKBP-FK506, an Immunophilin-Immunosuppressant Complex
4. RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
5. CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.
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