Elevated liver transaminases among patients with psychiatric disorders

Author:

Ali Eman1,Abdel maksoud Mona Ahmed2,Arafa Shaymaa M3,Ibrahim Doaa3,Hassan Ahmed El-Sayed45,Awwad Omnia6,Elbeltagy Ahmed M.7,Elmahdi Essam89,Elgarhi Reham10,Embaby Ahmed11

Affiliation:

1. Psychiatry Department, Faculty of Medicine, Zagazig University

2. Tropical Medicine Department, Faculty of Medicine, Zagazig University[aff_start], [/aff_end]Zagazig[aff_start], [/aff_end]Egypt

3. Psychiatry Department, Faculty of Medicine, AlAzhar University for Girls, Cairo

4. Medical Physiology Department, Faculty of Medicine, Zagazig University, Zagazig

5. Basic Medical Sciences Department, Faculty of Medicine, Sulaiman Al Rajhi University, Al-Bukayriyah, Saudi Arabia

6. Family Medicine and Health Informatics Specialist at Ministry of Health and Population, Zagazig

7. Clinical Pathology Department, Faculty of Medicine, Mansoura University

8. Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

9. Internal Medicine Department, Faculty of Medicine, Shaqra University, Dawadmi, Saudi Arabia

10. Clinical Pharmacology Department, Faculty of Medicine, Zagazig University

11. Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Abstract

Hepatocyte injury is assessed by serum aspartate transaminase and alanine transaminase estimation. In psychiatric populations, antipsychotic drugs (AD) are culprit in hepatic dysfunction. To assess transaminitis among psychiatric patients treated by AD. This cross-sectional study was conducted in Zagazig University Hospitals in Egypt, from December 2022 to February 2023. A total of 135 adult patients aged ≥ 18 years, were diagnosed with psychiatric disorders after exclusion of patients receiving any hepatotoxic drugs, viral hepatitis, having chronic liver or kidney diseases, diabetes mellitus, mental retardation, and pregnant females. Among the 135 patients, 104 (77.0%) were males. Their age was 32 ± 9, The most popular used class of AD was atypical AD 84 (62.2%). The overall incidence of transaminitis among patients receiving AD was 23/135 (17.04%) of patients; 13 (56.5%) were on atypical AD compared to 10 (43.5%) patients receiving combined AD, without any statistically significant difference. The use of AD in patients with psychiatric disorders is potentially safe with minimal transaminitis (<one-fold elevation). However, baseline and regular monitoring of serum aminotransferase is recommended during treatment.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Pharmacology (medical),Psychiatry and Mental health

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