Primary Cutaneous Peripheral T-Cell Lymphoma With Follicular Helper T-Cell Phenotype: Report of 2 Epstein–Barr Virus–Positive Cases

Author:

Chiang Chien-Ta1,Chuang Shih-Sung2,Lin Hsuen-Fu3,Li Wei-Hsuan4,Chiang Ying-Yi56,Chen Bo-Jung78

Affiliation:

1. Pathologist, Department of Pathology, Far Eastern Memorial Hospital, New Taipei City, Taiwan;

2. Pathologist, Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan;

3. Hematologist Oncologist, Department of Hematology and Medical Oncology, Mennonite Christian Hospital, Hualien, Taiwan;

4. Dermatologist, Department of Dermatology, Mennonite Christian Hospital, Hualien, Taiwan;

5. Dermatologist, Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan;

6. Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;

7. Pathologist, Department of Pathology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; and

8. Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Abstract

Abstract:Primary cutaneous T-cell lymphoma is distinct from nodal T-cell lymphoma clinically and pathologically. Recently, primary cutaneous follicular helper T-cell lymphoma (PC-TFHL) has been described as a peripheral T-cell lymphoma with T-follicular helper (TFH) cell phenotype. PC-TFHL usually presents as multiple plaques and nodules of skin with an indolent clinical course, but without association with Epstein–Barr virus. In this article, we report 2 rare cases of PC-TFHL which are Epstein–Barr virus–positive and with an aggressive clinical course. We discuss the challenges in the differential diagnoses, particularly with primary cutaneous extranodal NK/T-cell lymphoma, and nodal T-cell lymphoma of TFH origin with secondary cutaneous involvement.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Dermatology,General Medicine,Pathology and Forensic Medicine

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